Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake☆
Identifieur interne : 000319 ( Main/Exploration ); précédent : 000318; suivant : 000320Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake☆
Auteurs : Jane C. Munday [Royaume-Uni] ; Karla E. Rojas L Pez [Royaume-Uni] ; Anthonius A. Eze [Royaume-Uni] ; Vincent Delespaux [Belgique] ; Jan Van Den Abbeele [Belgique] ; Tim Rowan [Royaume-Uni] ; Michael P. Barrett [Royaume-Uni] ; Liam J. Morrison [Royaume-Uni] ; Harry P. De Koning [Royaume-Uni]Source :
- International Journal for Parasitology, Drugs and Drug Resistance [ 2211-3207 ] ; 2013.
Abstract
► Diminazene transporter in
Url:
DOI: 10.1016/j.ijpddr.2013.01.004
PubMed: 24533295
PubMed Central: 3862423
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000379
- to stream Pmc, to step Curation: 000379
- to stream Pmc, to step Checkpoint: 000272
- to stream Ncbi, to step Merge: 000224
- to stream Ncbi, to step Curation: 000224
- to stream Ncbi, to step Checkpoint: 000224
- to stream Main, to step Merge: 000319
- to stream Main, to step Curation: 000319
Le document en format XML
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Rojas L Pez</name><affiliation wicri:level="4"><nlm:aff id="aff2">Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Eze, Anthonius A" sort="Eze, Anthonius A" uniqKey="Eze A" first="Anthonius A." last="Eze">Anthonius A. Eze</name><affiliation wicri:level="4"><nlm:aff id="aff2">Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Delespaux, Vincent" sort="Delespaux, Vincent" uniqKey="Delespaux V" first="Vincent" last="Delespaux">Vincent Delespaux</name><affiliation wicri:level="1"><nlm:aff id="aff3">Institute of Tropical Medicine, Nationalestraat 155, B-2000 Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Institute of Tropical Medicine, Nationalestraat 155, B-2000 Antwerp</wicri:regionArea><wicri:noRegion>B-2000 Antwerp</wicri:noRegion></affiliation></author><author><name sortKey="Van Den Abbeele, Jan" sort="Van Den Abbeele, Jan" uniqKey="Van Den Abbeele J" first="Jan" last="Van Den Abbeele">Jan Van Den Abbeele</name><affiliation wicri:level="1"><nlm:aff id="aff3">Institute of Tropical Medicine, Nationalestraat 155, B-2000 Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Institute of Tropical Medicine, Nationalestraat 155, B-2000 Antwerp</wicri:regionArea><wicri:noRegion>B-2000 Antwerp</wicri:noRegion></affiliation></author><author><name sortKey="Rowan, Tim" sort="Rowan, Tim" uniqKey="Rowan T" first="Tim" last="Rowan">Tim Rowan</name><affiliation wicri:level="3"><nlm:aff id="aff4">GALVmed, Pentlands Science Park, Bush Loan, Edinburgh, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>GALVmed, Pentlands Science Park, Bush Loan, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Barrett, Michael P" sort="Barrett, Michael P" uniqKey="Barrett M" first="Michael P." last="Barrett">Michael P. Barrett</name><affiliation wicri:level="4"><nlm:aff id="aff1">Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Morrison, Liam J" sort="Morrison, Liam J" uniqKey="Morrison L" first="Liam J." last="Morrison">Liam J. Morrison</name><affiliation wicri:level="4"><nlm:aff id="aff1">Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5">Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Roslin Institute, University of Edinburgh, Easter Bush, Midlothian</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="De Koning, Harry P" sort="De Koning, Harry P" uniqKey="De Koning H" first="Harry P." last="De Koning">Harry P. De Koning</name><affiliation wicri:level="4"><nlm:aff id="aff2">Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author></analytic><series><title level="j">International Journal for Parasitology, Drugs and Drug Resistance</title><idno type="eISSN">2211-3207</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Graphical abstract</title><p><fig id="f0040" position="anchor"><graphic xlink:href="fx2"></graphic></fig></p></sec><sec><title>Highlights</title><p>► Diminazene transporter in <italic>Trypanosoma congolense</italic> has been proposed to be TcoAT1. ► Here, <italic>TcoAT1</italic> was cloned and functionally expressed in <italic>Trypanosoma brucei</italic>. ► TcoAT1 did not mediate the uptake of diminazene, only of purine nucleosides. ► Expression of TcoAT1 did not alter drug sensitivity in trypanosomes. ► We conclude that TcoAT1 is a transporter for purine nucleosides, not for diminazene.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Al Salabi, M I" uniqKey="Al Salabi M">M.I. 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De Koning</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Witola, W H" uniqKey="Witola W">W.H. Witola</name></author><author><name sortKey="Inoue, N" uniqKey="Inoue N">N. Inoue</name></author><author><name sortKey="Ohashi, K" uniqKey="Ohashi K">K. Ohashi</name></author><author><name sortKey="Onuma, M" uniqKey="Onuma M">M. Onuma</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Belgique</li><li>Royaume-Uni</li></country><region><li>Écosse</li></region><settlement><li>Glasgow</li><li>Édimbourg</li></settlement><orgName><li>Université d'Édimbourg</li><li>Université de Glasgow</li></orgName></list><tree><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Munday, Jane C" sort="Munday, Jane C" uniqKey="Munday J" first="Jane C." last="Munday">Jane C. Munday</name></region><name sortKey="Barrett, Michael P" sort="Barrett, Michael P" uniqKey="Barrett M" first="Michael P." last="Barrett">Michael P. Barrett</name><name sortKey="Barrett, Michael P" sort="Barrett, Michael P" uniqKey="Barrett M" first="Michael P." last="Barrett">Michael P. Barrett</name><name sortKey="De Koning, Harry P" sort="De Koning, Harry P" uniqKey="De Koning H" first="Harry P." last="De Koning">Harry P. De Koning</name><name sortKey="Eze, Anthonius A" sort="Eze, Anthonius A" uniqKey="Eze A" first="Anthonius A." last="Eze">Anthonius A. Eze</name><name sortKey="Morrison, Liam J" sort="Morrison, Liam J" uniqKey="Morrison L" first="Liam J." last="Morrison">Liam J. Morrison</name><name sortKey="Morrison, Liam J" sort="Morrison, Liam J" uniqKey="Morrison L" first="Liam J." last="Morrison">Liam J. Morrison</name><name sortKey="Morrison, Liam J" sort="Morrison, Liam J" uniqKey="Morrison L" first="Liam J." last="Morrison">Liam J. Morrison</name><name sortKey="Munday, Jane C" sort="Munday, Jane C" uniqKey="Munday J" first="Jane C." last="Munday">Jane C. Munday</name><name sortKey="Rojas L Pez, Karla E" sort="Rojas L Pez, Karla E" uniqKey="Rojas L Pez K" first="Karla E." last="Rojas L Pez">Karla E. Rojas L Pez</name><name sortKey="Rowan, Tim" sort="Rowan, Tim" uniqKey="Rowan T" first="Tim" last="Rowan">Tim Rowan</name></country><country name="Belgique"><noRegion><name sortKey="Delespaux, Vincent" sort="Delespaux, Vincent" uniqKey="Delespaux V" first="Vincent" last="Delespaux">Vincent Delespaux</name></noRegion><name sortKey="Van Den Abbeele, Jan" sort="Van Den Abbeele, Jan" uniqKey="Van Den Abbeele J" first="Jan" last="Van Den Abbeele">Jan Van Den Abbeele</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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